Alexander L. Han

The paper introduces IGNITE, a framework that combines genetic data with functional genomics to prioritize immune drug targets, showing improved performance over genetic methods alone.

This study shows that genetic diversity improves the performance of intolerance metrics in identifying disease-related genes, with multi-ancestry data outperforming European-only datasets.

This study identifies big tau, a splice isoform of tau, as more abundant in brain regions resistant to Alzheimer's pathology and shows its protective properties in human patients.