Tumor-associated tissue-resident macrophages drive pancreatic cancer progression through IGF1-IGF1R signaling
Yuya Yamamoto, Kenta Takeuchi, Shunsuke Tabe, Ayumu Okumura, Kenji Aoshima, Ryotaro Eto, Takanori Konishi, Naoto Yamamoto, Yohei Miyagi, Masayuki Ohtsuka, Naoki Tanimizu, Hideki Taniguchi
This study identifies TRM-TAMs as drivers of PDAC progression via IGF1-IGF1R signaling and suggests stratifying patients based on TRM-TAM abundance could improve IGF1R-targeted therapy.
bioRxiv · May 12, 2026 · PreprintCancer Biology