Yohei Miyagi

Highly plastic macrophage niches orchestrate acquired quiescence and reactivation in breast-cancer bone metastasis

The paper identifies CXCL16 macrophages in bone metastases that transiently restrain cancer growth and G-CSF niches that promote reactivation, revealing CAF-bone-marrow interactions as a therapeutic target.

Tumor-associated tissue-resident macrophages drive pancreatic cancer progression through IGF1-IGF1R signaling

This study identifies TRM-TAMs as drivers of PDAC progression via IGF1-IGF1R signaling and suggests stratifying patients based on TRM-TAM abundance could improve IGF1R-targeted therapy.

Integrated cell atlas and tumoroids chart pancreatic cancer therapeutic targets

The paper integrates single-cell transcriptomes and spatial transcriptomics to identify therapeutic targets in pancreatic cancer by analyzing cell states and ligand-receptor interactions in tumoroids.

Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers

The paper develops and validates multi-ancestry polygenic risk scores for LUAD in East Asian never-smokers, showing improved risk prediction compared to East Asian-only models.