Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection
Gema María Esteban-Ortega, Elena Torres-Campos, Margarita Díaz‐Guerra
The paper demonstrates that excitotoxicity-induced TrkB-FL downregulation is due to retrograde transport to the Golgi and shows that a neuroprotective peptide can interfere with this process to preserve Golgi stability and neuronal survival in stroke.
Cell Death and Disease · Aug 29, 2025Peer-reviewedNeuroscience