Margarita Díaz‐Guerra

This study shows that the intracellular domain of TrkB-T1 promotes stroke-like effects through neurotoxicity and glial reactivity.

The paper demonstrates that excitotoxicity-induced TrkB-FL downregulation is due to retrograde transport to the Golgi and shows that a neuroprotective peptide can interfere with this process to preserve Golgi stability and neuronal survival in stroke.

The paper identifies TrkB-T1 isoform-specific protein interactions and shows that interfering with them reduces neuroinflammation and neurotoxicity in a mouse stroke model.