Mengchao Yao

The paper constructs a model of the core endogenous network to simulate cell fate transitions in C. elegans embryogenesis and predicts AB cell transdifferentiation trajectories.

This study uses a network dynamics model to analyze glioma stem cells' role in glioma hierarchy, identifying stable states and transitional states linked to tumor heterogeneity and therapy resistance.

The paper explains the evolution of telencephalon anterior-posterior patterning through bifurcations in a gene network, supported by first-principle theory and experimental validation.