Author
Goethe University FrankfurtORCID 0000-0001-8190-9213Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Mohit Misra, Zhicheng Cui, Marie‐Catherine Drigeard Desgarnier…·Viola Nähse
This paper determines the crystal structures of DFCP1's ATPase domain with ADP and ATP analogues, revealing structural elements that regulate ATP hydrolysis and omegasome dynamics.
Deep Chatterjee, Verena Dederer, Landon Vu Nguyen…·Sebastian Mathea
The paper identifies novel kinase:Rab pairs and characterizes substrate recognition determinants for Rab phosphorylation by kinases like LRRK2.
Nicolai D. Raig, Katherine J. Surridge, Marta M. Sanz Murillo…·Stefan Knapp
Hybrid type-II inhibitors RN277 and RN341 target inactive LRRK2 with far fewer kinase off-targets than Rebastinib, preserve S935 phosphorylation, and rescue kinesin motility in vitro.
Sebastian Mandel, Thomas Hanke, Sebastian Mathea…·Stefan Knapp
The paper repurposes a benzoxazepinone scaffold originally designed for RIPK1 inhibition to develop a novel type-III LIMK1/2 inhibitor with high selectivity.