Jie Sheng

This study uses single-nucleus multiomic sequencing to analyze gene expression and chromatin accessibility in the Down syndrome prefrontal cortex, revealing widespread dysregulation in metabolic, synaptic, and neuroinflammatory pathways.

The paper constructs a gene regulatory network resource across species and brain regions to study neurogenesis dynamics and their links to neurodevelopmental disorders.

The paper identifies genes and regulatory networks driving electrophysiological maturation of neurons in primate prefrontal cortex, with implications for autism.

This study identifies reduced WNT signaling in Down syndrome progenitors, leading to fewer COUP-TFII+ interneurons and impaired neurogenesis.

This study shows that a short Nutlin-3 treatment in young FMR1-deficient mice prevents long-term neurogenic and cognitive deficits in adulthood.

The paper uses manifold learning to align single-cell transcriptomic and electrophysiological data, revealing gene expression-electrophysiology relationships and developmental trajectories in mouse neurons.