Sara Knaack

The paper shows that chronic stress and voluntary running induce distinct molecular programs in parvalbumin interneurons, with stress increasing KAT6A and H3K23 acetylation in the frontal cortex.

This study uses single-nucleus multiomic sequencing to analyze gene expression and chromatin accessibility in the Down syndrome prefrontal cortex, revealing widespread dysregulation in metabolic, synaptic, and neuroinflammatory pathways.

The paper identifies genes and regulatory networks driving electrophysiological maturation of neurons in primate prefrontal cortex, with implications for autism.

The paper uses single-nucleus sequencing to identify oxidative stress and metabolic changes in Down syndrome basal forebrain neurons at birth.

This paper introduces DRMN, a method to infer cell type-specific transcriptional networks from multi-omic data, showing it accurately predicts cis-regulators and models network dynamics.

HiC-Reg predicts high-resolution Hi-C interaction matrices from regulatory signals, identifying topologically associated domains and CTCF motifs.