Pubudu Kumarage

This study uses single-nucleus multiomic sequencing to analyze gene expression and chromatin accessibility in the Down syndrome prefrontal cortex, revealing widespread dysregulation in metabolic, synaptic, and neuroinflammatory pathways.

The paper constructs a gene regulatory network resource across species and brain regions to study neurogenesis dynamics and their links to neurodevelopmental disorders.

The paper uses single-nucleus sequencing to identify oxidative stress and metabolic changes in Down syndrome basal forebrain neurons at birth.