Denis Becquet

This study creates a novel mouse model with deletion of Necdin and Magel2 genes, revealing functional interactions and phenotypes relevant to Prader-Willi Syndrome.

The paper identifies 1791 RNAs directly interacting with Neat1 in paraspeckles, showing Neat1 binds over 30% of paraspeckle-targeted transcripts and preferentially binds their 5' ends.

The paper identifies mRNAs regulated by Neat1 deletion in rat pituitary cells, revealing both circadian and non-circadian effects and their association with key biological processes.

The paper identifies a 15-nucleotide sequence in the 3'UTR of calreticulin mRNA that mediates nuclear retention by paraspeckles and suggests HNRNPK as a bridging protein.