Bingbing X. Li

This study identifies protein age as a factor affecting PROTAC efficacy, showing that pre-existing proteins are degraded more efficiently than newly synthesized ones.

This paper identifies clofibric acid as a SYVN1 ligand and demonstrates its use in developing SYVN1-dependent BRD4 PROTACs with improved degradation efficiency.

The paper introduces CG-SLENP, a chemical genetics method to selectively label existing and newly synthesized proteins, showing differential modulation of these pools by a small molecule ligand.