Keith D. Zientek

This study shows that GNL3 SUMOylation is essential for homologous recombination repair of DNA double-strand breaks and identifies potential therapeutic targets in breast cancer.

This paper identifies clofibric acid as a SYVN1 ligand and demonstrates its use in developing SYVN1-dependent BRD4 PROTACs with improved degradation efficiency.

This study establishes a mouse model of Crybb3 loss-of-function and identifies proteomic changes in the lens, including downregulation of multiple proteins and altered transcription factor activation.

This study investigates the effects of α-crystallin gene knockout on zebrafish lens development, finding that loss of A-crystallin causes lens defects while loss of Ba- or Bb-crystallin does not.