Graham K. Murray

This study combines rare variant burden scores and common variant polygenic risk scores to improve genetic risk prediction for schizophrenia, hypertrophic cardiomyopathy, and major depressive disorder.

GWAS of 2,347 neuroimaging phenotypes identifies genetic loci and structures related to cortical development, cellular processes, and neurodevelopmental disorders.

This study identifies genetic loci for gastrointestinal disorders and finds a link between the nervous system and the gastrointestinal tract.

The paper investigates how prior beliefs influence perception in early psychosis, finding differences in reliance on cognitive and perceptual priors between prodromal, psychotic, and control groups.

The paper assesses reinforcement learning deficits in psychosis risk groups and finds they are not linked to schizophrenia polygenic risk in the general population.

The paper investigates the relationship between jumping to conclusions bias, IQ, psychosis, and polygenic risk scores in a case-control study, finding that IQ significantly predicts JTC bias while schizophrenia PRS does not.

This paper develops a deep learning framework to segment the paracingulate sulcus from MRI scans and estimate segment lengths, achieving a Dice score over 0.77.

This study identifies 11 novel genome-wide significant loci for anhedonia, finds genetic correlations with major depressive disorder, schizophrenia, and bipolar disorder, and shows polygenic associations with brain structure.

The paper investigates how precision-weighting of prediction error signals in the superior frontal cortex affects learning, is influenced by dopamine, and is impaired in psychosis.

This study investigates dopaminergic modulation of prediction error responses in OCD using fMRI and computational modeling, finding bidirectional remediation of exaggerated cingulate signaling with dopamine agonists and antagonists.

This paper identifies distinct neuroanatomical patterns of gray matter changes associated with hallucination status in psychiatric versus neurodegenerative disorders through meta-analyses and systematic reviews.

This study shows early psychosis patients jump to conclusions due to perceiving higher information sampling costs, not due to noisy decision making.

This study investigates salience processing abnormalities in first episode psychosis patients using fMRI, finding reduced neural signaling in midbrain and cortical regions for various salience types.

This study examines the relationship between reward anticipation brain activity and psychopathology in children, finding a single significant association between right parsorbitalis activation and psychotic-like experiences.

This study investigates how dopamine modulates the precision of cortical unsigned prediction errors and its impact on learning.

This study examines reward prediction error signalling in individuals with first episode psychosis and those at risk for psychosis, finding abnormal midbrain and prefrontal cortex activation compared to healthy controls.