Massimo Gennarelli

This study combines rare variant burden scores and common variant polygenic risk scores to improve genetic risk prediction for schizophrenia, hypertrophic cardiomyopathy, and major depressive disorder.

The paper links miR-137 and its target genes to schizophrenia risk through emotion processing in the prefrontal cortex, showing allele associations with brain activation patterns.

The paper investigates the conservation of rare schizophrenia risk variants across diverse populations and finds consistent burden in constrained genes.

This paper ranks antidepressants based on their similarity to gene expression profiles of treatment responders, finding escitalopram and citalopram show high rankings in some cell lines.

The paper identifies consistently RNA-edited sites in human blood, links them to RNA processing genes, and finds correlations with cell types and biological variables.