Author

Nolan Priedigkeit

Broad InstituteORCID 0000-0001-8330-5210Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adrian V. LeeiD· 2 shared Zheqi LiiD· 2 shared Abdalla M. WedniD· 1 shared Adam BrufskyiD· 1 shared Alan H. WellsiD· 1 shared Alexander Chih-Chieh ChangiD· 1 shared Alinés Lebrón-TorresiD· 1 shared Amanda M. ClarkiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Adrian V. LeeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyBreast Cancer ResearchPeer-reviewedJun 19, 2025

Hope for Others: Research Results from the University of Pittsburgh Rapid Autopsy Program for Breast Cancer

Alexander Chih-Chieh Chang, Marija Balić, Tanner L. Bartholow…·Steffi Oesterreich

The paper describes the Hope for Others rapid autopsy program for metastatic breast cancer, detailing its protocols, sample collection, and findings on metastasis research and model development.

4 citations

humanclinical cohort / trial

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GenomicsClinical Cancer ResearchPeer-reviewedMay 16, 2025

Clinicogenomic characterization of inflammatory breast cancer

Nolan Priedigkeit, Beth T. Harrison, Robert E. Shue…·Filipa C. Lynce

This study analyzes genomic alterations in a large IBC cohort, finding high TP53 mutation frequency and NOTCH pathway enrichment, but no major genomic differences compared to non-IBC cases.

5 citations

humanwhole-exome sequencing

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedSep 20, 2022

Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer.

Thong Luong, Zheqi Li, Nolan Priedigkeit…·Kara Anne Bernstein

This study shows that Hrq1/RECQL4 regulates DNA intrastrand crosslink repair and its misregulation contributes to genomic instability in cancer.

10 citations

yeaststatistical model

𝕏 PostBluesky