The cytokine structural homologs IL-1β and IL-1Ra have distinct dynamical character that potentially influence their roles in allosteric regulation of the IL-1 receptor.
Glorisé Torres-Montalvo, Taylor R. Cole, Anthony C. Bishop, Rosana Lopes, A. Joshua Wand
This study compares the dynamic properties of IL-1β and IL-1Ra using NMR relaxation to show that their distinct functional roles in IL-1R signaling arise from differences in conformational entropy at the receptor interface.
bioRxiv · Sep 14, 2026 · PreprintBiophysics