Key Nucleation Stages and Associated Molecular Determinants and Processes in pH-Induced Formation of Amyloid Beta Oligomers as Revealed by High-Speed AFM
Lei Feng, Hiroki Watanabe, Paul J. Molino, Gordon G. Wallace, Son Lam Phung, Takayuki Uchihashi, Michael J. Higgins
This study uses high-speed AFM to visualize pH-induced AB42 peptide nucleation and identifies key molecular stages in oligomer formation.
bioRxiv · Oct 17, 2020 · PreprintNeuroscience