BioengineeringbioRxivPreprint
AI-Guided Precision in Antibody Humanization: Structural Modeling to Minimize Immunogenicity and Preserve Efficacy
Haiying Wang, Chunqiu Xia, Yupeng Zhu…·Quan Yu
This study uses AI to humanize a murine antibody by grafting only essential paratopes, reducing immunogenicity while preserving efficacy and developability.
DOI 10.1101/2025.03.09.641110