David P. Finn

This study identifies sex-dependent changes in endocannabinoid signaling in pain-modulatory brain regions following nerve injury in rats.

The paper investigates the role of the endocannabinoid system in placebo analgesia, finding that FAAH substrates and low beta-endorphin levels are associated with pain reduction.

This study shows that repeated restraint stress worsens post-surgical pain and anxiety in rats through β-adrenergic receptor activation and spinal NLRP3-IL1β signaling.

This study investigates the relationship between the endocannabinoid system and pain sensitivity in humans using quantitative sensory testing, finding no significant associations overall but a specific link between FAAH substrates and pressure pain thresholds.

The paper identifies conserved transcriptional changes across sex and species after peripheral nerve injury and predicts a new analgesic treatment using a drug-gene interactome analysis.

The paper investigates altered phasic relationships between hippocampal place cells, theta, and gamma rhythms in Ts65Dn mice compared to control mice, linking these changes to learning and memory deficits in Down Syndrome.

This paper develops a computerized decision support system for predicting Alzheimer’s disease severity using cognitive and clinical measures, showing improved accuracy over biomarker-based models.