Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome
Alejandro J. Brenes, Harunori Yoshikawa, Dalila Bensaddek, Bogdan Andrei Mirauta, Daniel D. Seaton, Jens L. Hukelmann, Hao Jiang, Oliver Stegle, Angus I. Lamond
The paper shows that erosion of X chromosome inactivation in human iPSCs leads to increased protein expression from X-linked and autosomal genes, altering protein-RNA correlations and increasing protein content.
bioRxiv · Mar 18, 2020 · PreprintMolecular Biology