Dalila Bensaddek

Optimized Time-segmented Acquisition Expands Peptide and Protein Identification in TIMS-TOF Pro Mass Spectrometry

The paper introduces a novel time-segmented acquisition method for TIMS-TOF mass spectrometry, improving peptide and protein identification by optimizing ion separation.

Population-scale proteome variation in human induced pluripotent stem cells

The paper characterizes proteome variation across 202 human iPSC lines, identifies 700 pQTLs, and links pQTLs to disease-associated GWAS variants.

Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome

The paper shows that erosion of X chromosome inactivation in human iPSCs leads to increased protein expression from X-linked and autosomal genes, altering protein-RNA correlations and increasing protein content.

Single-cell RNA-seq of differentiating iPS cells reveals dynamic genetic effects on gene expression

The paper uses single-cell RNA-seq of differentiating iPS cells from 125 donors to identify expression quantitative trait loci influencing gene expression during endoderm differentiation.

Common genetic variation drives molecular heterogeneity in human iPSCs

This study analyzes 522 human iPSCs to identify genetic sources of phenotypic variation, finding 5-25% of variation in traits like differentiation capacity is due to individual differences.

The Prolylhydroxylase PHD2 Modulates Centromere Function through the Hydroxylation of CENP-N

This study shows PHD2 hydroxylates CENP-N, regulating its localization and interaction with CENP-L, which affects CENP-A stability at centromeres.