Author

Nathan Guerin

Duke UniversityORCID 0000-0001-8378-7854Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:protein sequence· 2 Approach:statistical model· 2

Frequent Co-Authors

Bruce Randall DonaldiD· 2 shared Andreas FeichtneriD· 1 shared Eduard StefaniD· 1 shared Henry ChildsiD· 1 shared Pei ZhouiD· 1 shared Teresa KasereriD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

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6 top collaborators · 9 mutual co-author links

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2 shared papersBioinformatics

Bruce Randall DonaldORCID

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2 papers

Recent·Most cited

BioinformaticsLecture notes in computer sciencePeer-reviewedJan 1, 2024

DexDesign: A new OSPREY-based algorithm for designing de novo D-peptide inhibitors

Nathan Guerin, Henry Childs, Pei Zhou, Bruce Randall Donald

DexDesign is a new OSPREY-based algorithm for designing D-peptide inhibitors targeting PDZ domains, generating peptides predicted to bind tighter than endogenous ligands.

DOI 10.1007/978-1-0716-3989-4_25

humanprotein sequence

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BioinformaticsbioRxivPreprintJan 18, 2022

Resistor: an algorithm for predicting resistance mutations using Pareto optimization over multistate protein design and mutational signatures

Nathan Guerin, Andreas Feichtner, Eduard Stefan…·Bruce Randall Donald

RO_SCPLOWESISTORC_SCPLOW predicts resistance mutations by optimizing four criteria using Pareto frontiers, identifying clinically relevant mutations in EGFR and BRAF inhibitors.

1 citation

humanprotein sequence

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