This study examines how sequence-dependent DNA bending affects liquid crystalline phases of gapped DNA constructs, finding a bending angle of ~11 degrees per A-tract and reduced thermal stability of bent duplexes.

DOI 10.1021/acs.biomac.5c01978

experimental assay

𝕏 PostBluesky

BiophysicsLangmuirPeer-reviewedNov 10, 2025

Locked Nucleic Acid Stabilized Liquid Crystalline Phases

Sineth G. Kodikara, Samuel Sprunt, Hamza Balci

This study quantifies how single LNA modifications in DNA base pairs affect the thermal stability of liquid crystalline phases formed by gapped DNA constructs.

1 citation

DNA methylationexperimental assay

𝕏 PostBluesky

BiophysicsACS Macro LettersPeer-reviewedJan 22, 2025

Sequence-Dependent Liquid Crystalline Ordering of Gapped DNA

Sineth G. Kodikara, J. T. Gleeson, Antal I. Jákli…·Hamza Balci

This study examines how poly-adenine sequences affect liquid crystalline phases in gapped DNA, identifying new phase behaviors and linking them to poly-A sequence properties.

3 citations

experimental assay

𝕏 PostBluesky