Sineth G. Kodikara

This study shows CRISPR-dCas13d can repress VEGF translation by destabilizing its G-quadruplex IRES under hypoxia, without affecting mRNA levels.

This study investigates how telomeric overhang architecture affects small-molecule ligand accessibility by analyzing binding stoichiometry and cooperativity in G-quadruplex structures.

This study examines how sequence-dependent DNA bending affects liquid crystalline phases of gapped DNA constructs, finding a bending angle of ~11 degrees per A-tract and reduced thermal stability of bent duplexes.

This study quantifies how single LNA modifications in DNA base pairs affect the thermal stability of liquid crystalline phases formed by gapped DNA constructs.

This study investigates how molecular crowding affects the accessibility and structure of telomeric overhangs with multiple G-quadruplexes using smFRET and FRET-PAINT.

This study examines how poly-adenine sequences affect liquid crystalline phases in gapped DNA, identifying new phase behaviors and linking them to poly-A sequence properties.

This study shows that CRISPR-dCas9 targeting G-quadruplex structures in the c-Myc promoter can activate or suppress gene expression, with dual targeting achieving significant reductions in mRNA and protein levels.

This paper demonstrates a method to reset and reuse single-molecule microfluidic chambers using photocleavable biotin and UV light, enabling at least 10 cycles without surface degradation.

This study investigates how the shelterin complex protects the telomeric junction by bridging single- and double-stranded telomeric DNA, enhancing POT1 binding stability and junction protection.