Author

Haruhito Totani

University of MichiganORCID 0000-0001-8395-8975Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alanna V. Van HuizeniD· 1 shared Antonio Morales‐HernándeziD· 1 shared Dewmi Sandaru Rathnayake· 1 shared Dirk LoeffleriD· 1 shared Emilia KooiengaiD· 1 shared Federica ZanottiiD· 1 shared Ishani Sharma· 1 shared Jessica Nunes· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Alanna V. Van HuizenORCID

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1 paper

Recent·Most cited

Elevated endocytic trafficking mediated by GPRASP2 maintains HSC fidelity.

Alanna V. Van Huizen, Mattieu Zhai, Haruhito Totani, Dewmi Sandaru Rathnayake, Emilia Kooienga, Ishani Sharma, Zakiya Kelley, Madeleine Rodgers, Federica Zanotti, lance Palmer, Kate Tisdale, Preeti Dabas, Jessica Nunes, Dirk Loeffler, Shondra Pruet-Miller, , Shannon McKinney‐Freeman

The paper shows that elevated endocytic trafficking via GPRASP2 maintains HSC quiescence and prevents functional exhaustion.

bioRxiv · Feb 11, 2026 · PreprintCell Biology