Author
St. Jude Children's Research HospitalORCID 0000-0002-5598-3636Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Alanna V. Van Huizen, Mattieu Zhai, Haruhito Totani…·Shannon McKinney‐Freeman
The paper shows that elevated endocytic trafficking via GPRASP2 maintains HSC quiescence and prevents functional exhaustion.
Philip Moresco, Jonathan P. Kastan, Jung‐In Yang…·Douglas T. Fearon
This study shows pancreatic cancer cells secrete keratin-19 (KRT19) without a signal peptide by entering the ER via its head domain and through secretory autophagy, enabling CXCL12 capture to exclude T cells.
Jordan A. Pearson, Jung‐In Yang, Sean Krivitsky…·Douglas T. Fearon
This study shows that crosslinked CXCR4 on T cells reduces their motility and increases adhesion through a non-Gi-dependent pathway involving PTK2B and integrin β4.
Aditya Barve, Adam B. Cornwell, Pramika Sriram…·Shannon McKinney‐Freeman
This study shows senolytics like ABT-263 restore bone marrow function in sickle cell disease by reversing HSC dysfunction and senescence in mice.