GeneticsbioRxivPreprint
CHOP-c-JUN complex plays a critical role in liver proteotoxicity induced by mutant Z alpha-1 antitrypsin.
Sergio Attanasio, Gwladys Gernoux, Rosa Ferriero…·Nicola Brunetti‐Pierri
The paper identifies the CHOP-c-JUN complex as a key driver of liver proteotoxicity in AAT deficiency by enhancing SERPINA1 transcription and ATZ accumulation.