Author

Lizbeth Hedstrom

Brandeis UniversityORCID 0000-0001-8432-3322Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 1 Organism:fungi (other)· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander W. SarkisiD· 1 shared Douglas L. TheobaldiD· 1 shared Jens C. FrisvadiD· 1 shared Jens Laurids SørenseniD· 1 shared Kåre Lehmann NielseniD· 1 shared Teis Esben SøndergaardiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperEvolutionary Biology

Alexander W. SarkisORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 23, 2026

An activity-resistance tradeoff constrains enzyme evolution

Alexander W. Sarkis, Jens Laurids Sørensen, Teis Esben Søndergaard…·Lizbeth Hedstrom

This paper investigates the evolutionary tradeoff between enzyme activity and resistance to mycophenolic acid (MPA) and finds that resistance correlates with reduced catalytic efficiency across both ancestral and extant enzymes.

DOI 10.1073/pnas.2602068123

fungi (other)proteomics

𝕏 PostBluesky