Author

Alexander W. Sarkis

Brandeis UniversityORCID 0009-0009-0554-0667Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 1 Organism:fungi (other)· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Douglas L. TheobaldiD· 1 shared Jens C. FrisvadiD· 1 shared Jens Laurids SørenseniD· 1 shared Kåre Lehmann NielseniD· 1 shared Lizbeth HedstromiD· 1 shared Teis Esben SøndergaardiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperEvolutionary Biology

Douglas L. TheobaldORCID

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1 paper

Recent·Most cited

Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 23, 2026

An activity-resistance tradeoff constrains enzyme evolution

Alexander W. Sarkis, Jens Laurids Sørensen, Teis Esben Søndergaard…·Lizbeth Hedstrom

This paper investigates the evolutionary tradeoff between enzyme activity and resistance to mycophenolic acid (MPA) and finds that resistance correlates with reduced catalytic efficiency across both ancestral and extant enzymes.

DOI 10.1073/pnas.2602068123

fungi (other)proteomics

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