Author

Scott Bottoms

Technical University of MunichORCID 0000-0001-8457-2134Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alexandra EssebieriD· 1 shared Ariane MoraiD· 1 shared Boštjan KobeiD· 1 shared Brad BaldersoniD· 1 shared Burkhard RostiD· 1 shared Connie M. RossiD· 1 shared Dietmar HaltrichiD· 1 shared Elizabeth M. J. GillamiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Alexandra EssebierORCID

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1 paper

Recent·Most cited

BioinformaticsPLoS Computational BiologyPeer-reviewedOct 24, 2022

Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)

Gabriel Foley, Ariane Mora, Connie M. Ross…·Mikael Bodén A

The paper introduces GRASP, a method for ancestral sequence reconstruction that handles large datasets and indels, demonstrating its ability to generate biologically active enzyme ancestors.

70 citationstop 4%

protein sequencestatistical model

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