Author
The University of QueenslandORCID 0000-0003-0378-793XUnclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
Recent·Most cited
Wayne A. Johnston, Raine E. S. Thomson, Juan Alfaro-Palma…·James B. Y. H. Behrendorff
This study demonstrates the use of a Leishmania cell-free system to express and assay human P450 enzymes 3A4 and 2D6, showing distinct reductase preferences and drug interaction consistency.
Gabriel E. Boyle, Katherine A. Sitko, Jared Galloway…·Douglas M. Fowler
The paper uses deep mutational scanning to analyze CYP2C19 variants, revealing a tradeoff between substrate specificity and protein abundance.
Gabriel Foley, Ariane Mora, Connie M. Ross…·Mikael Bodén A
The paper introduces GRASP, a method for ancestral sequence reconstruction that handles large datasets and indels, demonstrating its ability to generate biologically active enzyme ancestors.