Respiration-Deficient Cells Require Pyruvate Carboxylase to Suppress Asparagine Auxotrophy
Ruobing Cui, Keun Woo Ryu, Yi Fu, Ziad Bakouny, Dayi Li, Tamar Kavlashvili, Agnel J. Sfeir, Craig B. Thompson
The paper shows that respiration-deficient cells rely on pyruvate carboxylase to prevent asparagine auxotrophy, with effects dependent on mitochondrial heteroplasmy levels.
Nature Metabolism · Oct 27, 2026Peer-reviewedCell Biology