Yi Fu

The paper shows that respiration-deficient cells rely on pyruvate carboxylase to prevent asparagine auxotrophy, with effects dependent on mitochondrial heteroplasmy levels.

This paper develops a method to engineer specific mtDNA deletions in human cells using end-joining machinery and targeted endonucleases, revealing a 75% heteroplasmy threshold for mitochondrial dysfunction.

This study evaluates variant callers on ATAC-seq data to discover SNVs and indels, finding VarCA outperforms individual callers in both bulk and single-cell data.

The paper shows that mitochondrial DNA breaks trigger a type I interferon response through nuclear sensing, enhancing immune surveillance against genotoxic stress.

BreakCA identifies indels in regulatory regions using ChIP-seq and ATAC-seq, finding recurrent indels in neuroblastoma cell lines that may be oncogenic.