Author

Carmine D’Amico

University of HelsinkiORCID 0000-0001-8477-4553Unclaimed ORCID profile · follow to get notified of new preprints

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Assay:multiome· 1 Research Focus:protein design· 1

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Mauri A. KostiaineniD· 1 shared Mykkänen Miska· 1 shared Sharon Saarinen· 1 shared Ville Säkkinen· 1 shared

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2026-2026 · peak 1/yr

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Mauri A. KostiainenORCID

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1 paper

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Synthetic BiologybioRxivPreprintAug 6, 2026

Impact of Coding Region Accessibility and Uridine Chemistry on Translation in mRNA-DNA Hybrid Origami

Carmine D’Amico, Mykkänen Miska, Sharon Saarinen…·Mauri A. Kostiainen

This study investigates how folding mRNA into a six-helix bundle affects translation, finding that only the start of the coding sequence needs to be accessible, and that modifications like 5-methoxyuridine and N1-methylpseudouridine influence translation levels.

DOI 10.64898/2026.06.25.734245

multiomeexperimental assay

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