Author

Mauri A. Kostiainen

Aalto UniversityORCID 0000-0002-8282-2379Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:multiome· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1

Frequent Co-Authors

Sharon Saarinen· 2 shared Boxuan SheniD· 1 shared Carmine D’AmicoiD· 1 shared Esa‐Pekka KumpulaiD· 1 shared Iris SeitziD· 1 shared Jeroen J. L. M. CornelisseniD· 1 shared Juha T. HuiskoneniD· 1 shared Julia Wierzchowiecka· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersSynthetic Biology

Sharon Saarinen

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2 papers

Recent·Most cited

Impact of Coding Region Accessibility and Uridine Chemistry on Translation in mRNA-DNA Hybrid Origami

Carmine D’Amico, Mykkänen Miska, Sharon Saarinen, Ville Säkkinen, Mauri A. Kostiainen

This study investigates how folding mRNA into a six-helix bundle affects translation, finding that only the start of the coding sequence needs to be accessible, and that modifications like 5-methoxyuridine and N1-methylpseudouridine influence translation levels.

bioRxiv · Aug 6, 2026 · PreprintSynthetic Biology

Folding of mRNA-DNA origami for controlled translation and viral vector packaging

Iris Seitz, Sharon Saarinen, Julia Wierzchowiecka, Esa‐Pekka Kumpula, Boxuan Shen, Jeroen J. L. M. Cornelissen, Veikko Linko, Juha T. Huiskonen, Mauri A. Kostiainen

This study investigates how design parameters affect mRNA-DNA origami folding and translation efficiency, showing the importance of ribosome-binding sequences and demonstrating their encapsulation in virus capsids for enhanced delivery.

Advanced Materials · Feb 27, 2025Peer-reviewedBioengineering