GeneticsbioRxivPreprint
Genetic alteration of ferredoxin NADP+-reductase or cysteine desulfurase in piperaquine-resistant Plasmodium berghei restores susceptibility to lumefantrine and abolishes the impact of probenecid, verapamil, and cyproheptadine
Fagdéba David Bara, Loise Ndung’u, Noah Machuki Onchieku…·Daniel Muthui Kiboi
The paper investigates how genetic alterations in SufS or FNR genes affect LM and PQ resistance in P. berghei and shows that these changes restore LM susceptibility and negate chemosensitizer effects.
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