Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in non-alcoholic steatohepatitis and reversed by alternate day fasting
Madhulika Tripathi, Karine Cécile Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Soni Gupta, Suganya Sakthivel, Wei Wen Teo, Yadanar Than Naing, Kabilesh Arul, Keziah Tikno, Sung‐Hee Park, Yajun Wu, Lijin Wang, Boon‐Huat Bay, Lei Sun, , Brijesh Kumar Singh
This study identifies Esrra's role in regulating Rplp1-mediated translation of lysosomal and autophagy proteins during NASH, showing that alternate day fasting can reverse these effects.
bioRxiv · Nov 16, 2021 · PreprintMolecular Biology