The paper identifies Esrra as a master regulator of adaptive hepatic translation during prolonged starvation by inducing Rplp1 expression and lysosome/autophagy protein translation.

bioRxiv · Jan 9, 2024 · PreprintMolecular Biology

Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in non-alcoholic steatohepatitis and reversed by alternate day fasting

Madhulika Tripathi, Karine Cécile Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Soni Gupta, Suganya Sakthivel, Wei Wen Teo, Yadanar Than Naing, Kabilesh Arul, Keziah Tikno, Sung‐Hee Park, Yajun Wu, Lijin Wang, Boon‐Huat Bay, Lei Sun, , Brijesh Kumar Singh

This study identifies Esrra's role in regulating Rplp1-mediated translation of lysosomal and autophagy proteins during NASH, showing that alternate day fasting can reverse these effects.

bioRxiv · Nov 16, 2021 · PreprintMolecular Biology

Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression

Eveline Bruinstroop, Jin Zhou, Madhulika Tripathi, Winifred Wing Yiu Yau, Anita Boelen, Brijesh Kumar Singh, Paul M. Yen

Molecular Metabolism · Jun 5, 2021Peer-reviewedMolecular Biology

Autocrine IL11 cis-signaling in hepatocytes is an initiating nexus between lipotoxicity and non-alcoholic steatohepatitis

Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh Kumar Singh, Sonia Pankaj Chothani, Benjamin Ng, Wei‐Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S. J. Ko, Shamini Guna Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, , Anissa Anindya Widjaja

The paper shows that autocrine IL11 signaling in hepatocytes drives lipotoxicity and NASH by causing lipoapoptosis and reactive oxygen species, with protection seen in Il11ra1-deleted mice.

Nature Communications · Jan 4, 2021Peer-reviewedMolecular Biology