Brijesh Kumar Singh

The paper identifies Esrra as a master regulator of adaptive hepatic translation during prolonged starvation by inducing Rplp1 expression and lysosome/autophagy protein translation.

This study shows that inhibiting IL11 improves healthspan in aged mice by reversing metabolic dysfunction, sarcopenia, and frailty.

This study identifies Esrra's role in regulating Rplp1-mediated translation of lysosomal and autophagy proteins during NASH, showing that alternate day fasting can reverse these effects.

The paper investigates IL11-driven fibrosis mechanisms, showing ERK, not STAT3, drives fibrogenesis and identifies a novel role for nintedanib in inhibiting pro-fibrotic translation.

The paper shows that autocrine IL11 signaling in hepatocytes drives lipotoxicity and NASH by causing lipoapoptosis and reactive oxygen species, with protection seen in Il11ra1-deleted mice.

This study identifies IL-11 as a key driver of HSC-to-myofibroblast transformation in NASH, showing that targeting IL-11 reduces fibrosis and inflammation in preclinical models.