Alysha S Taylor

The paper develops CHARLIE, a method to identify interruptions and errors in expanded tandem repeats using targeted sequencing, validated on Huntington's disease and myotonic dystrophy type 1 samples.

The paper shows that PDI, a conserved protein, alters endometrial function in species with different implantation strategies by modifying transcriptomes and secretomes.

The paper demonstrates that CRISPR-Cas9 nickase can contract CAG/CTG repeats in patient-derived cells and improve molecular and behavioral phenotypes in Huntington's disease.

This study investigates the effects of in-utero sex bias on reproductive traits in female pigs, finding that birth weight has a greater impact than litter sex ratio on ovarian reserve and uterine development.

Repeat Detector accurately measures expanded tandem repeats and identifies interrupted alleles in targeted DNA sequencing data from Huntington's disease patients.

The paper develops a system to study how expanded CAG/CTG repeats affect gene silencing via epigenome editing and finds that repeats reduce silencing effectiveness.