Author

Lorène Aeschbach

University of Lausanne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Vincent DioniD· 3 shared Alysha S TayloriD· 2 shared Hilal Ahmed LashueliD· 2 shared Adelie Y. S. Tan· 1 shared Alice E. DavidsoniD· 1 shared Alicia C. BorgeaudiD· 1 shared Bin YangiD· 1 shared Branduff McAllisteriD· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMolecular Biology

Vincent DionORCID

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Author profile →

5 papers

Recent·Most cited

Repeat Detector: versatile sizing of expanded tandem repeats and identification of interrupted alleles from targeted DNA sequencing

Alysha S Taylor, Dinis Barros, Nastassia Gobet, Thierry Schuepbach, Branduff McAllister, Lorène Aeschbach, Emma L. Randall, Evgeniya Trofimenko, Eleanor R. Heuchan, Paula Barszcz, Marc Ciosi, Joanne Morgan, Nathaniel J. Hafford‐Tear, Alice E. Davidson, Thomas H. Massey, , Vincent Dion

Repeat Detector accurately measures expanded tandem repeats and identifies interrupted alleles in targeted DNA sequencing data from Huntington's disease patients.

NAR Genomics and Bioinformatics · Oct 6, 2022Peer-reviewedNeuroscience

N-terminal mutant Huntingtin deposition correlates with CAG repeat length and disease onset, but not neuronal loss in Huntington's disease

Florence E. Layburn, Adelie Y. S. Tan, Nasim F. Mehrabi, Maurice A. Curtis, Lynette J. Tippett, Nathan Riguet, Lorène Aeschbach, Hilal Ahmed Lashuel, Mike Dragunow, Richard L. M. Faull, Malvindar K. Singh‐Bains

This study screens antibodies against huntingtin (Htt) to analyze Htt distribution and aggregates in HD brain tissue, finding correlations between CAG repeat length and Htt aggregation, but not neuronal loss.

bioRxiv · May 3, 2022 · PreprintNeuroscience

Comparative analysis of total alpha-synuclein (αSYN) immunoassays reveals that they do not capture the diversity of modified αSYN proteoforms

Lara Petricca, Nour Chiki, Layane Hanna-El-Daher, Lorène Aeschbach, Ritwik Burai, Erik Stoops, Mohamed-Bilal Fares, Hilal Ahmed Lashuel

The paper compares three commercial alpha-synuclein immunoassays and finds they fail to capture the diversity of modified alpha-synuclein proteoforms.

Journal of Parkinson s Disease · May 3, 2022Peer-reviewedNeuroscience

Expanded CAG/CTG Repeats Resist Gene Silencing Mediated by Targeted Epigenome Editing

Bin Yang, Alicia C. Borgeaud, Marcela Buřičová, Lorène Aeschbach, Oscar Rodríguez‐Lima, Gustavo A. Ruiz Buendía, Cinzia Cinesi, Alysha S Taylor, Tuncay Baubec, Vincent Dion

The paper develops a system to study how expanded CAG/CTG repeats affect gene silencing via epigenome editing and finds that repeats reduce silencing effectiveness.

Human Molecular Genetics · Sep 7, 2021Peer-reviewedMolecular Biology

Minimizing carry-over PCR contamination in expanded CAG/CTG repeat instability applications

Lorène Aeschbach, Vincent Dion

The paper introduces a method to reduce PCR carry-over contamination in expanded CAG/CTG repeat instability studies using Uracil N-Glycosylase and dUTP.

Scientific Reports · Dec 15, 2017Peer-reviewedMolecular Biology