Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewed
Design, Optimization and Development of RIPK1 Degraders with Improved Pharmacokinetic and Pharmacodynamic Properties
Dong Lu, Xin Qi Yu, Hanfeng Lin…·Jin Wang
This study designs and evaluates a novel RIPK1 degrader, LD5097, showing potent degradation activity, favorable pharmacokinetics, and enhanced antitumor effects in cancer models.
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