Jakub M. Tomczak

This study shows that changing nutrient levels in osteosarcoma cells significantly alters gene expression, revealing nutrient-dependent gene regulation and potential therapeutic targets.

The paper identifies potential protease inhibitors targeting host ER proteases for antiviral drug development against orthohantaviruses, with Compound E showing the highest binding confidence.

This paper introduces rbio1, a biology reasoning model trained using soft verification via biological world models, achieving state-of-the-art performance on perturbation prediction.

The paper develops a framework to integrate metabolic gene expression and nutrient availability into genome-scale metabolic models to study osteosarcoma metabolism under different glucose and glutamine conditions.