Wayne J. Hawthorne

The paper compares 10 machine learning workflows to identify genes associated with insulin transcript presence in human pancreatic single-cell transcriptomes, finding Random Forest to be highly predictive.

The paper shows human gallbladder epithelial cells retain a pro-endocrine pancreatic transcriptional program, enabling insulin production and immune protection in type 1 diabetes.

This study shows that FAP deficiency in diet-induced obese mice reduces liver steatosis, insulin resistance, and glucose intolerance while increasing FGF-21 levels.