Cancer BiologybioRxivPreprint
Reversible therapeutic resistance in EGFR mutant lung cancer caused by RB1 loss induced lineage plasticity
Letian Zhang, Meenalakshmi Chinnam, Bradley Balk…·David W. Goodrich
This study shows RB1 loss in EGFR mutant lung cancer leads to reversible lineage plasticity, accelerating resistance to EGFR TKI therapy through non-genetic mechanisms.
3 citations