Eduardo Cortes Gomez

This study quantifies cancer stemness in prostate cancer across progression stages, showing its association with therapy resistance, poor survival, and lineage plasticity.

This study identifies sex-associated epigenetic and transcriptional programs in muscle-invasive bladder cancer, showing distinct DNA methylation and gene expression patterns between males and females, with conservation in a mouse model.

This study identifies STAG2's role in regulating chromatin architecture and gene expression in muscle invasive bladder cancer, revealing its context-specific activation and repression of genes involved in oncogenic signaling.

This study identifies an opioid-mediated signaling axis in pancreatic cancer that drives extracellular matrix remodeling and tumor aggressiveness, suggesting methylnaltrexone as a potential therapeutic.

The paper investigates how two alleles of the CHRFAM7A gene, through divergent cytoskeletal evolution, lead to distinct brain organization and potential susceptibility to neuropsychiatric diseases.

This study shows RB1 loss in EGFR mutant lung cancer leads to reversible lineage plasticity, accelerating resistance to EGFR TKI therapy through non-genetic mechanisms.

This study identifies HNF1A as an oncogenic driver of PDAC metastasis through upregulation of FGFR4 and shows that FGFR4 inhibition reduces metastasis in vitro and in vivo.

This study shows that EZH2 influences the evolution of aggressive prostate cancer subtypes but is not essential for neuroendocrine prostate cancer development.

This study identifies a Th1/Th17 imbalance driven by IFN{gamma} that causes cytokine release syndrome and neutropenia in CAR-T therapy, suggesting IFN{gamma} blockade as a potential treatment.

This study shows that mitochondrial hypoxia induces APOBEC3G-mediated RNA editing in lymphocytes, leading to metabolic changes and reduced proliferation.