John H. Sinard

This study identifies clonal determinants of liver metastasis and poor survival in uveal melanoma by analyzing genomic and transcriptional features of primary and metastatic tumors.

This paper develops a genetically engineered mouse model of uveal melanoma that recapitulates human disease progression and immune microenvironment features, revealing phenotypic plasticity and cooperative genetic drivers.

This paper develops a systems approach to improve Lynch syndrome diagnosis by enhancing tumor testing and referral processes, resulting in increased genetic testing and LS diagnosis rates.