Harriet M. Kluger

Phenotypic and functional characterization of tumor-reactive T cells in malignant pleural effusions

This study characterizes T cells in malignant pleural effusions (MPE) and finds they have lower exhaustion and higher cytotoxic potential compared to tumor T cells, suggesting MPE as a better source for TIL therapy.

Clonal determinants of organotropism and survival in metastatic uveal melanoma

This study identifies clonal determinants of liver metastasis and poor survival in uveal melanoma by analyzing genomic and transcriptional features of primary and metastatic tumors.

CAR-T-drug conjugate against solid tumor

This paper introduces CAR-T-drug conjugates (CAR-T-D-C) to improve CAR-T therapy for solid tumors by combining chemotherapy with CAR-T cells, enhancing tumor infiltration and immune response.

Perturbational single-cell profiling of patient tumors defines lineage- and context-specific programs of innate immune resistance

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance

The paper develops a computational method to analyze single-cell RNA-seq data to study cell-cell interactions in tumors, showing that CD40 agonist enhances immune checkpoint blockade by modulating myeloid-T cell interactions.

SORBET: Automated cell-neighborhood analysis of spatial transcriptomics or proteomics for interpretable sample classification via GNN

SORBET uses geometric deep learning to predict phenotypes from spatial transcriptomics and proteomics data, showing improved accuracy over existing methods.

SIMVI reveals intrinsic and spatial-induced states in spatial omics data

SIMVI disentangles intrinsic and spatial-induced variations in spatial omics data, revealing spatial effects and biological dynamics across multiple datasets.

Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells

The paper examines circulating T cells sharing TCRs with tumor-infiltrating T cells in metastatic melanoma patients, finding they exhibit effector gene signatures similar to tumor T cells.

Methods for detecting co-mutated pathways in cancer samples to inform treatment selection

The paper develops a method to detect co-mutated pathways in cancer samples and identifies enriched pathway pairs across six cancer types, suggesting potential mechanisms for immune evasion.