Florian A. Karreth

circPMS1-mediated LIM protein scaffolding promotes cytoskeletal remodeling and melanoma metastasis

This study identifies circPMS1 as a pro-metastatic circRNA in melanoma that promotes cytoskeletal remodeling and metastasis by scaffolding LIM proteins.

The small MAF transcription factor MAFG co-opts MITF to promote melanoma progression

This study identifies MAFG as a driver of melanoma progression by interacting with MITF to alter gene expression and promote a dedifferentiated melanoma phenotype.

PHGDH is a targetable driver of PDAC progression

This study identifies PHGDH as a driver of PDAC progression by maintaining glutamine metabolism and mTOR signaling, revealing a therapeutic vulnerability to glutamine antagonism in PHGDH-deficient tumors.

FRA1 drives melanoma metastasis through an actionable transcriptional network

This study identifies FRA1 as a driver of melanoma metastasis and shows that targeting its downstream genes AXL, CDK6, and FSCN1 suppresses metastasis and improves survival.

CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma

A multi-step immune-competent genetic mouse model reveals phenotypic plasticity in uveal melanoma

This paper develops a genetically engineered mouse model of uveal melanoma that recapitulates human disease progression and immune microenvironment features, revealing phenotypic plasticity and cooperative genetic drivers.

MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability

This study identifies PHGDH induction via MAPK and mTORC1 pathways as essential for melanoma formation and shows that combining BRAFV600E inhibition with serine restriction can target this vulnerability.

Genetic tools for the stable overexpression of circular RNAs

This paper develops genetic tools for stable circRNA overexpression in vitro and in vivo, demonstrating their utility in cell culture and mouse models.